2021 Jul 22. doi: 10.1245/s10434-021-10468-2. Epub 2020 Sep 15. EPIDEMIOLOGÍA The significant risk factors for LR were mitoses, tumor border (infiltrating vs. pushing), stromal cellularity (moderate/severe vs. mild), stromal atypia (severe vs. mild/absent), stromal overgrowth (severe vs. mild/absent), and tumor necrosis (positive vs. negative). Metaplastic changes are infrequent in the stromal and epithelial component of these tumors. El tumor pesó 2.150 grs. Caso Clínico La biopsia definitiva fue informada como Tumor Phyllodes Borderline o Tumor Phylodes maligno de Bajo Grado (según clasificación histológica WHO año 2002), de 17,5 x 15 x 13 cms. Se ha encontrado dentro â Página 25Borderline phyllodes tumor. This biphasic nodule shows distinct stromal hypercellularity, still preserving some epithelial structures. Se ha encontrado dentro â Página 99A borderline phyllodes tumor has a slight probability of metastasis (<5%) and is more likely to recur locally than the benign variety. They tend to grow quickly, but they rarely spread outside the breast. Phyllodes tumors are ⦠DDx: Fibroadenoma. Margin-positive BCS alone showed poorest LC regardless of tumor size (62.5%, p = 0.007). Clin Breast Cancer. Genetic analysis will potentially supplement classical histologic examination in order to improve our management of these tumors. Epub 2019 Jun 17. The number of recurrences was too low, and the information on the size of the closest resection margin was too sparse to estimate an adequate margin size for excision of nonmalignant PTs. El tumor phyllodes es un tumor bifásico infrecuente, constituido por elementos epiteliales y un estroma fusocelular denso, constituye 0,3 % a 0,9 % de las neoplasias de la mama en la mujer y el 2 % -3 % de todos los tumores fibroepiteliales mamarios (1), en el sexo masculino hay pocos casos descritos (4). Definition. Pada tahun 1981 WHO mengadopsi penamaan tumor phyllodes dan membaginya menjadi tipe benign, borderline, dan malignant berdasarkan karakteristik stroma. El estudio anatomopatólógico de la pieza, revela la existencia de un Tumor Phyllodes borderline, con margen de resección menor a 0,1 cm focalmente. Debido a esto su tratamiento sigue siendo controversial. 7,8. Epub 2019 Apr 11. Pioderma gangrenoso como síndrome paraneoplásico de un tumor tipo Phyllodes Borderline Pyoderma gangrenosum as paraneoplastic syndrome of a Phylloides tumor, Borderline type Diego FernanDo Severiche, omar velanDia, eugenia lucía SalDarriaga ⢠Bogotá, D.C. (ColomBia) El tumor Phyllodes de mama es un tumor poco frecuente que se engloba dentro de los tumores fibroepiteliales de mama, con un amplio abanico de presentación clínica y comportamiento biológico. La mama más frecuentemente afectada fue la izquierda (56,7%), siendo en los tumores benignos la localización más habitual la retroareolar y en los tumores malignos los cuadrantes internos. Grading. Information on age, size of primary tumor and recurrence, histological grade, surgical treatment, margin size, and local recurrence were collected from the national Danish Pathology Register. Se ha encontrado dentro â Página 368Clinical suspicion of phyllodes tumor ⢠Rapidly growth palpable mass ... Wide excision Fibroadenoma Benign phyllodes Borderline or malign phyllodes Observe ... Keywords: pyoderma gangrenosum, Phyllodes tumor, paraneoplastic syndrome. This study sought to evaluate recurrence rates and identify factors associated with local and distant failure. doi: 10.1016/j.clbc.2019.04.003. In borderline and malignant phyllodes tumors metastases to distant anatomic sites can occur. Entre un 35 a 64% de los tumores phyllodes son benignos y el resto subdividido en borderline y malignos.7,8 El término tumor phyllodes exhibe una amplia gama de comportamiento clínico y patológico; se debe Would you like email updates of new search results? 2013 Oct;141(3):353-63. doi: 10.1007/s10549-013-2684-x. ¿Cómo Los Tumores Filodes afectan Su Riesgo de padecer Cáncer de seno? Chen WH, Cheng SP, Tzen CY, Yang TL, Jeng KS, Liu CL, Liu TP. 8600 Rockville Pike Se ha encontrado dentro â Página 659Phyllodes Tumor Phyllodes tumors are rare fibroepithelial tumors that display a spectrum of clinical and pathologic behaviors that are benign , borderline ... Clínicamente son tumores voluminosos, de consistencia firme y de superficie lobulada. The stroma is markedly cellular and the stromal cells show marked nuclear pleomorphism. Phyllodes tumors are a fibroepithelial tumor composed of an epithelial and a cellular stromal component. A Phyllodes tumor is available in three different types of Benign, borderline, malignant. Descrita por primera vez por Johannes Müller en 1838 (cistosarcoma phyllodes). ⦠Pioderma gangrenoso como síndrome paraneoplásico de un tumor tipo Phyllodes Borderline Pyoderma gangrenosum as paraneoplastic syndrome of a Phylloides tumor, Borderline type Diego FernanDo Severiche, omar velanDia, eugenia lucía SalDarriaga ⢠Bogotá, D.C. (ColomBia) 2021 Jan 20;39(3):178-189. doi: 10.1200/JCO.20.02647. Online ahead of print. This systematic review and meta-analysis aimed to investigate local recurrence (LR) rates among the three grades (benign, borderline, and malignant) of phyllodes tumors (PTs). Teresa Carrascosa Mirón, Sagrario Fuerte Ruíz, Javier Rodríguez Padilla, Pablo Pastor Riquelme, José María Jover Navalón The risk of LR was significantly increased by borderline versus benign PTs (odds ratio [OR] 2.00; 95% confidence interval [CI] 1.68-2.38) and malignant versus borderline PTs (OR 1.28; 95% CI 1.05-1.55). It is classified as benign, borderline, or malignant, and can mimic benign masses. doi: 10.1016/j.clbc.2019.04.003. Se ha encontrado dentro â Página 182PHYLLODES TUMOR The series of mammary tumors known as phyllodes tumors continue ... understanding of the borderline between benign and malignant difficult; ... Width of margins in phyllodes tumors of the breast: the controversy drags on?-a systematic review and meta-analysis. Tokai J Exp Clin Med., Vol. 2019 Dec;26(Suppl 3):637-638. doi: 10.1245/s10434-019-07434-4. The Characteristics of Local Recurrence After Breast-Conserving Surgery Alone for Malignant and Borderline Phyllodes Tumors of the Breast (KROG 16-08). Clipboard, Search History, and several other advanced features are temporarily unavailable. Online ahead of print. There was a significant increase in CD10 expression in the stromal cells as the lesions progressed from benign to borderline and malignant phyllodes tumors (p = 0.001). Próximamente tendré cirugía, al ser mi mama pequeña y tener que dejar unos márgenes de seguridad grandes, me han recomendado una mastectomía, así como si me hubieran tirado un jarro de agua fría. El tumor Phyllodes se clasifica en tres etapas: benignos, borderline( baja potencialidad de malignidad) y malignos. Los tumores filodes son tumores del seno poco comunes que se originan en el tejido conectivo (estroma). There are numerous mitoses 24. Malignant and borderline phyllodes tumors of the breast: a multicenter study of 362 patients (KROG 16-08) Malignant and borderline phyllodes tumors with positive margins after surgery have high LR rates. After treatment by margin-negative BCS alone, patients with large malignant phyllodes tumors ⥠5 cm also have heightened risk of LR. El tratamiento es quirúrgico y la extensión de la cirugía depende de las características del tumor y de la mama afectada. Phyllodes tumors tend to invade the connective tissue of the breast. 2013 Mar-Apr;33(2):162-8. doi: 10.5144/0256-4947.2013.162. El tumor phyllodes, también denominado cistosarco - ma filodes, enfermedad de Brodie, mioma intracanalicu - lar gigante o mixoma mamario gigante, es una neoplasia Phyllodes tumors of the breast are uncom-mon fibroepithelial neoplasms that have potential for recur-rence. 200. Phyllodes tumor presents a morphologic continuum from benign to malignant. Phyllodes Tumor : High-grade with Sarcoma, NOS. Se ha encontrado dentroIncidence of local recurrence in benign , borderline and malignant phyllodes tumor ; relation of recurrence to histologic classification The incidence of ... Phyllodes tumor includes benign, borderline, and malignant Fibroadenoma Invasive or in situ cancer Fibroadenoma or indeterminate Phyllodes tumor includes benign, borderline, and malignant Invasive or in situ cancer Observe Wide excisionc without axillary stagingd See appropriate guidelines Excisional biopsya See findings above Wide excisionc El tratamiento del tumor Phyllodes benigno es quirúrgico, realizándose extirpación completa de la lesión. Regional recurrence occurred in 2 (0.6%) patients and distant metastasis (DM) developed in 19 (5.2%) patients. Tumor Phyllodes. Phyllodes Tumor : High-grade with Squamous metaplasia. Phyllodes tumor of the breast: clinicopathologic analysis of 22 cases ABSTRACT Introduction. Ann Surg Oncol. eCollection 2021. En tumores de gran tamaño puede ser necesaria la mastectomía simple4. In their least aggressive form, phyllodes tumors behave like benign fibroadenomas, although with a propensity to recur locally. Phyllodes tumor of the breast: a clinic-pathologic study of 77 cases in a Hispanic cohort Carlos Andres Ossa 1, ... presentaron mas porcentaje de tumores borderline y malignos (p <0.001). Tumors Los tumores Phyllodes representan menos del 1% de todos los cánceres de mama. J Surg Oncol. Bogach J, Shakeel S, Wright FC, Hong NJL. Se ha encontrado dentro â Página 384Furthermore, sonography cannot distinguish between malignant, borderline, ... The classification of phyllodes tumor is based on histologic features of the ... Spitaleri G, Toesca A, Botteri E, Bottiglieri L, Rotmensz N, Boselli S, Sangalli C, Catania C, Toffalorio F, Noberasco C, Delmonte A, Luini A, Veronesi P, Colleoni M, Viale G, Zurrida S, Goldhirsch A, Veronesi U, De Pas T. Crit Rev Oncol Hematol. Zhao J, Gao M, Ren Y, Cao S, Wang H, Ge R. Front Endocrinol (Lausanne). Jang JH, Choi MY, Lee SK, Kim S, Kim J, Lee J, Jung SP, Choe JH, Kim JH, Kim JS, Cho EY, Lee JE, Nam SJ, Yang JH. 2021 Sep 7. doi: 10.1007/s00330-021-08232-x. Epub 2014 Sep 17. El tumor phyllodes es poco frecuente, pero debe ser tenido en cuenta ante todo tumor mamario que aumenta rápidamente de tamaño. Less than 1 % of breast tumors are phyllodes. Phyllodes Tumor : High-grade with Chondrosarcoma. Se ha encontrado dentro â Página 153... to facilitate appropriate clinical management, phyllodes tumors are divided into benign, borderline, and malignant categories based on a combination of ... Assessment of quantitative dynamic contrast-enhanced MRI in distinguishing different histologic grades of breast phyllode tumor. [Treatment of phyllodes tumours of the breast: evaluation of 66 cases and literature review]. Fibroepithelial tumours of the breast-a review. The study also assessed various risk factors for LR. Phyllodes tumors are a fibroepithelial tumor composed of an epithelial and a cellular stromal component. They may be considered benign, borderline, or malignant depending on histologic features including stromal cellularity, infiltration at the tumor's edge, and mitotic activity. The review incorporated 54 studies with 9234 individual cases. Occasionally, a phyllodes tumour grows fairly quickly and can be quite large (often between 40â50mm). La mama más frecuentemente afectada fue la izquierda (56,7%), siendo en los tumores benignos la localización más habitual la retroareolar y en los tumores malignos los cuadrantes internos. After treatment by margin-negative BCS alone, patients with large malignant phyllodes tumors ⥠5 cm also have heightened risk of LR. They are most common in women in their 30s and 40s, although women of any age can be affected. Se ha encontrado dentro â Página 186(A and B) Borderline phyllodes tumor with pushing borders, stromal expansion, and high cellularity. (B) Borderline phyllodes tumor 10. 11. 12. 13. 14. 15. Tumor Phyllodes. Se clasifican en benignos, borderline o malignos, en base a factores histológicos. tumores phyllodes benignos fue la tumorectomía (96,4 %) mientras que se indicó una mastectomía en 4 (44,4 %) de los tumores borderline y en 2 (50 %) de los tumores malignos. Se ha encontrado dentro â Página 467Unlike fibroadenoma, phyllodes tumors may enlarge quickly and can visibly distort ... phyllodes tumors are classified as benign, borderline, or malignant. Phyllodes tumors are uncommon fibroepithelial breast tumors that are capable of a diverse range of biologic behaviors. Breast Cancer Res Treat. The authors independently reviewed the abstracts and extracted data for LR rates and LR risk factors. Phyllodes tumors (PTH) are an unusual group of mammary lesions exhibiting an imperfect clinicopathologica/ correlation. Front Oncol. ASO Author Reflections: Local Recurrence Risk and Risk Factors of Breast Phyllodes Tumors. Phyllodes (fil-oy-deez) tumors are a rare form of breast tumor; they can be benign (not cancerous), malignant (cancerous), or borderline (having characteristics of both). The required size of this margin (= the distance between the phyllodes tumor and the edge of the ⦠Width of margins in phyllodes tumors of the breast: the controversy drags on?-a systematic review and meta-analysis. Background: This systematic review and meta-analysis aimed to investigate local recurrence (LR) rates among the three grades (benign, borderline, and malignant) of phyllodes tumors (PTs). At Tumor phyllodes Radioterapia Su uso está indicado en casos de enfermedad recurrente regional y metástasis sintomática. Slit-like spaces may absent in a borderline phyllodes or a malignant phyllodes. El objetivo es reconocer nódulos y áreas que pudieran ser susceptibles de sospecha. Cuando realizamos una ecografía de mama buscamos cambios en la normalidad de esta ecoarquitectura. Huge borderline phyllodes breast tumor with repeated recurrences and progression toward more malignant phenotype: a case report and literature review OncoTargets Ther. It may recur following resection. 9 . Epub 2020 Jan 10. Su crecimiento consta de 2 fases: una primera fase larga de crecimiento lento y ⦠2020 Apr;9(2):452-458. doi: 10.21037/gs.2020.01.17. Borderline phyllodes tumor. El tumor Phyllodes supone menos del 1% de todos los tumores de mama. Se ha encontrado dentro â Página 740Benign and borderline tumors can recur, especially with positive or close margins, but metastases are generally seen only with malignant phyllodes tumor. doi: 10.1016/j.suronc.2011.04.007. Gigantomastia por tumor Phyllodes borderline. Kesimpulan borderline phyllodes tumor Berdasarkan anamnesis, pemeriksaan fisis serta pemeriksaan penunjang yang telah dilakukan maka diagnosis pasien ini adalah Borderline Phyllodes Tumor. MeSH 2021 Mar 1;14(1):123-133. doi: 10.1159/000510741. Se ha encontrado dentroHistologically, phyllodes tumors have a hypercellular stroma that is out of ... Phyllodes tumors are categorized as benign, borderline, and malignant based ... Please enable it to take advantage of the complete set of features! Tumores filodes del seno. The subgroup analysis showed that breast-conserving surgery versus mastectomy and positive versus negative surgical margins were significantly associated with an increased LR risk only in malignant PTs. Tumores filodes del seno. Se ha encontrado dentro â Página 196Phyllodes Tumors Smear Pattern: Low to Borderline Phyllodes Tumors: Predominantly Large Epithelial Tissue Fragments With Myoepithelial Cells and Bare ... Bogach J, Shakeel S, Wright FC, Hong NJL. Ann Saudi Med. They are classified as benign, borderline, and malignant, based on a constellation of histologic characte- Giant Benign Mammary Phyllodes Tumor: Report of a Case and Review of the Literature. This site needs JavaScript to work properly. A study is made of 26 PTH (22 benign, 3 malignant and 1 borderline), together [50]. Se caracte-rizan por presentar rápido crecimiento, se originan del estroma periductal y tienen compo-nentes tanto epitelial como del estroma 4. The recurrence rates are higher for borderline and malignant phyllodes tumors. Los márgenes quirúrgicos fueron negativos, todos a más de 1cm. Hola, yo también he sido diagnosticada a través de biopsia con un tumor phyllodes borderline y otro más pequeñito. 2021 Jul 8;11:688182. doi: 10.3389/fonc.2021.688182. They are classified as benign, borderline, and malignant, based on a constellation of histologic characte- The incidence of metastases is higher in malignant phyllodes tumors. Learn more about phyllodes tumors. Thirty-one patients received adjuvant radiation therapy (RT), and those who received adjuvant chemotherapy were excluded from the study. 2021 Jan;185(1):21-37. doi: 10.1007/s10549-020-05924-8. Clínicamente se presenta como un tumor duro, multinodular, bien definido, móvil y doloroso. Los márgenes quirúrgicos fueron negativos, todos a más de 1cm. Some pathologists don't believe in cellular fibroadenoma - they call everything with stromal cellularity a phyllodes tumour. Se ha encontrado dentro â Página 853... Benign phyllodes Tumor cell TERT +/âother oncogenes/TSG Borderline/malignant Phyllodes tumor cell e Pathology feature Benign Borderline Malignant Atypia ... El diagnóst ico de certeza sólo lo dio el exam en anatomopatológico dife-rido del material extirpado. Malignant tumors can sometimes metastasize to tissues such as lungs and bones. Se ha encontrado dentro â Página 134TABLE 10-2 Features of Benign, Borderline, and Malignant Phyllodes Tumors (PT) Features Benign PT Borderline PT Malignant PT Margins Well defined Largely ... os tumores phyllodes representan menos del 1% de los tumores mamarios 1-3. 2021 Jul 22. doi: 10.1245/s10434-021-10468-2. However, a precise molecular classification of these tumors has not yet been established. Phyllodes Tumor : High-grade with Rhabdomyosarcoma. Se ha encontrado dentro â Página 153... to facilitate appropriate clinical management, phyllodes tumors are divided into benign, borderline, and malignant categories based on a combination of ... Se ha encontrado dentro â Página 98In phyllodes tumors , estrogen receptor alpha and progesterone receptors are detected ... was high in benign but low in borderline and malignant phyllodes . What does borderline breast cancer mean? Please enable it to take advantage of the complete set of features! Choi N, Kim K, Shin KH, Kim Y, Moon HG, Park W, Choi DH, Kim SS, Ahn SD, Kim TH, Chun M, Kim YB, Kim S, Choi BO, Kim JH. Prevention and treatment information (HHS). The stroma is markedly cellular and the stromal cells show marked nuclear pleomorphism. The study also assessed various risk factors for LR. These are breast tumors that start in the stromal tissue of the breast. A benign, borderline, or malignant fibroepithelial neoplasm arising from the breast and rarely the prostate gland. Se clasifican en benignos, borderline o malignos, en base a factores histológicos. 3 , 4 Surgical treatment remained the upfront standard of care for all patients [5] , [6] , [7] ; however, further decision making regarding post-operative ⦠Se ha encontrado dentro â Página 61Phyllodes tumor has a wide range of spectrum from benign to borderline to malignant lesions depending on mitosis, tumor necrosis and pleomorphism. It may recur following resection. Toussaint A, Piaget-Rossel R, Stormacq C, Mathevet P, Lepigeon K, Taffé P. Breast Cancer Res Treat. El tumor phyllodes es poco frecuente, pero debe ser tenido en cuenta ante todo tumor mamario que aumenta rápidamente de tamaño. MED12 mutations in breast phyllodes tumors: evidence of temporal tumoral heterogeneity and identification of associated critical signaling pathways. Malignant phyllodes tumors account for approximately 6.5-27% of all phyllodes tumors [5, 8â11]. For borderline subtypes, only positive margins (p = 0.044) independently increased the risk of LR. Would you like email updates of new search results? Yi Z, Xie M, Shi G, Cheng Z, Zeng H, Jiang N, Wu Z. Eur Radiol. 2014 Oct. 21 (10):3304-9. A pesar de su clasificación en benignos, borderline y malignos, su comportamiento tiende a ser incierto. Los tumores Phyllodes agrupan un conjunto de patologías caracterizadas por presentar una arquitectura histológica estromal y epitelial; dividiéndose en benignos, borderline o ⦠7,8. con celularidad estromal alta, áreas de necrosis y hemorragia. En tumores de gran tamaño puede ser necesaria la mastectomía simple4. From 1981 to 2014, 362 patients with malignant (n = 235) and borderline (n = 127) phyllodes tumors were treated by breast-conserving surgery (BCS) or total mastectomy (TM) at 10 centers. 3, pp. Phyllodes tumors account for fewer than 1% of all breast lesions. Phyllodes tumors of the breast can be benign, malignant, or borderline. Los márgenes quirúrgicos fueron nega-tivos, todos a más de 1cm. Twenty-three recurrences had similar or lower histological grading than the primary tumor, one primary benign PT recurred as a tumor with unclear diagnosis, and one primary borderline PT recurred as malignant. They get their name from the leaf-like pattern in which they grow (phyllodes means leaf-like in Greek). J Clin Oncol. Conclusions: Crossref, Medline, Google Scholar: 18. Keywords: If a phyllodes tumor is suspected, women will typically need to undergo a needle or open surgical biopsy.This helps test the tumor for possible malignancy, and it may be then be considered benign, borderline or malignant. The risk of LR was significantly increased from benign to borderline to malignant PTs. Pioderma gangrenoso como síndrome paraneoplásico de un tumor tipo Phyllodes Borderline Pyoderma gangrenosum as paraneoplastic syndrome of a Phylloides tumor, Borderline type Diego Fernando Severiche 1 , Omar Velandia 2 , Eugenia Lucía Saldarriaga 3 ⢠Bogotá, D.C. (Colombia) The stroma is moderately cellular and the stromal cells show moderate nuclear atypia (hematoxylin-eosin, 23. Conclusions: Extensive squamous metaplasia within phyllodes tumor is rare and may occur in benign, borderline and malign subtypes. The stroma is moderately cellular and the stromal cells show moderate nuclear atypia (hematoxylin-eosin, 23. After treatment by margin-negative BCS alone, patients with large malignant phyllodes tumors ≥ 5 cm also have heightened risk of LR. The risk for the spreading of the (Benign Phyllodes, Borderline Phyllodes) tumor beyond the breast is very low for this type of cancer. Gigantomastia due to borderline Phyllodes tumor. Some doctors feel that an even wider margin of healthy tissue should be removed. Se ha encontrado dentro â Página 467Of note, even benign phyllodes tumors recur, and both borderline and malignant tumors have the ability to metastasize. Management of nonmetastatic phyllodes ... Próximamente tendré cirugía, al ser mi mama pequeña y tener que dejar unos márgenes de seguridad grandes, me han recomendado una mastectomía, así como si me hubieran tirado ⦠Virchows Arch. Malignant phyllodes tumor of the breast: treatment and prognosis. Ann R Coll Surg Engl. Bookshelf Phyllodes tumour affects 1% of the population and there is a higher percentage that this will be benign however can be borderline or malignant and treatment will vary depending on the diagnosis. Careers. Tras discusión del caso en Comité Multidisciplinar de patología mamaria, se decide realización de mastectomía simple y reconstrucción inmediata con colgajo libre abdominal tipo DIEP. Los tumores Phyllodes se clasifican en benignos, malignos y borderline 4-5. 2021 Jan;185(1):21-37. doi: 10.1007/s10549-020-05924-8. Tumor phyllodes Perinatol Reprod Hum 2013; 27 (2): 106-112 107 www.medigraphic.org.mx ficación como benignos, borderline o malignos. Se ha encontrado dentro â Página 172q borderline tumor shows 5â9 mitoses per 10 HPF, and may show a fibrosarcomatous component ... Phyllodes tumors require complete excision with free margins, ... Epub 2012 Apr 4. Nationwide retrospective study on Danish women aged 18 years or older, operated from 1999 to 2014, with resected benign or borderline PTs. Tumor Phyllodes de mama: Estudio clínico-patológico de 77 casos en una cohorte hispana. DM developed exclusively in malignant subtypes and a prior LR event increased the risk of DM by sixfold (HR 6.2, 95% CI 1.6-16.1, p = 0.001). El tumor phyllodes, también denominado cistosarco - ma filodes, enfermedad de Brodie, mioma intracanalicu - lar gigante o mixoma mamario gigante, es una neoplasia Malignant phyllodes tumor. Wide local excision with an adequate marg in of normal breast tissue is the preferred initial therapy for phyllodes tumor. The results do not justify wide excision margins of nonmalignant phyllodes tumors of the breast. This site needs JavaScript to work properly. Benign and borderline tumors are rare tumor types that have a positive outlook and high survival rate, while the risk of recurrence is typical for malignant breast tumors. Se clasifican en benignos, limítrofes o borderline y malignos en base a sus hallazgos histopatológicos. Tumor Phyllodes. For margin-negative BCS alone, 5-year LC rates for tumors ≥ 5 cm versus those < 5 cm were 71.8% versus 89.5% (p = 0.012). Debido a esto su tratamiento sigue siendo controversial.
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